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For example, studies and case reports have demonstrated that rifampin accelerates the metabolism of several drugs, including oral anticoagulants, oral contraceptives, glucocorticoids, digitoxin, quinidine, methadone, hypoglycemics, and barbiturates

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Archived from the original on 19 November 2020

For example, mTORC1 promotes survival by inhibiting apoptosis and autophagy, while its inhibition can sensitize cells to autophagy-dependent death, ferroptosis, or, in certain contexts, necroptosis and pyroptosis

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Future research is warranted to address these challenges and investigate the possibility of synergizing inhibitors of NADPH synthesis for novel combinatorial therapies with current chemotherapeutics