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Subsequent mutational analysis of a Drosophila GPx ( Dm GPx) also suggests a function for a conserved Asn residue that is necessary for the enzymatic function of the GPxs (361)

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5 The lens naturally contains high levels of antioxidants, including ascorbic acid (vitamin C) and glutathione, which work together to help keep the lens clear

Front Pharmacol:12

doi: 10.3390/molecules30010174 33 NigarSShimulIMHossainMSSultanaRAshaSHuqAO

Inhibition of the Xc- transport system by genetic (siRNA, CRISPR) or pharmacological means (Erastin, Sulfasalazine) impairs cystine transport and GSH synthesis, leading to the inactivation of GPX4 and induction of ferroptosis [14]