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Other CD44-mediated copper uptake mechanisms have been recently identified and their role in cancer demonstrated 14 but CD44 was not in our hit list apparently due to a low expression in ATP7B-KO HepG2 cells 13

Similarly, transgenic mice overexpressing Cyp7a1 were shown to become resistant to weight gain and fatty liver disease [35]

Thymosin-beta4 has a role in tissue repair and has been found to play an important role in protection, regeneration, and remodeling of injured or damaged tissues

NemethETuttleMSPowelsonJVaughnMBDonovanAWardDMet alHepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

Glycyl-l-histidyl-l-lysine-Cu(2+) rescues cigarette smoking-induced skeletal muscle dysfunction via a sirtuin 1-dependent pathway