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As we age, natural hormone production, cellular repair, and metabolic efficiency gradually decline

However, when evaluating a person with diabetes and signs and/or symptoms of neuropathy, it is important to remember that DPN is not the only possible cause of these signs and/or symptoms and that rare diabetic neuropathies or even neuropathies of other etiologies may be present (74) ( Figure 1 )

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The likelihood of pre-existing resistant clones is shaped by tumor size, baseline mutational burden, fitness costs, and microenvironmental constraints, making therapeutic failure an expected evolutionary outcome under strong selective pressure

More generally, this review not only presents genetic dependencies typically present in most tumors but also reveals unique characteristics of GBM in comparison to other tumors

Iranmanesh, A., Lizarralde, G