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As the disease progressed, the cerebrovascular lesions and ischemia became increasingly severe, and the cerebral microvascular distribution was difficult to observe

However, under stress, Nrf2 dissociates from KEAP1, translocates from the cytoplasm to the nucleus and binds antioxidant response elements, thereby activating the transcription of antioxidant defense genes such as HO-1, leading to the rapid clearance of ROS and the alleviation of oxidative damage (39)

Chimeric Genes Hybrid Proteins Pt A 326 340362 10.1016/S0076-6879(00)26064-3 [DOI] [PubMed] [Google Scholar] Vergis J

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