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In these areas, studies reported reduced activity of non-ETC mitochondrial enzymes, such as aconitase and pyruvate dehydrogenase

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International Journal of Bioassays 5(12):51635173 Izquierdo-Vega JA, Snchez-Gutirrez M, Del Razo LM (2008) Decreased in vitro fertility in male rats exposed to fluoride-induced oxidative stress damage and mitochondrial transmembrane potential loss

Low B12 can be caused by: Diet: B12 is found in high concentration in animal products like meat, eggs, and dairy

Recruitment of HIF-1 co-activators: p300/CBP P300 and CBP are the main transcriptional factors related to the activation of HIF-1-responsive genes with HAT activity [34, 188]

Notably, comparisons of these analogs are limited because efruxifermin and pegbelfermin have been evaluated in patients with confirmed NASH, while BIO89-100 has been studied in patients with less severe NAFLD