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This, in combination with the requirement for access to the amino group of cysteine, gives clues to the chemical reaction mechanism of iron- and VitB 6 -coordinated production of H 2 S

In castration-resistant prostate cancer (CRPC), enzalutamide enhances mitochondrial dependency, sensitizing cells to copper ionophores via lipoylated protein aggregation and Fe-S cluster destabilization [218]

The role of rapamycin in healthspan extension via the delay of organ aging

This metabolic flexibility is orchestrated by complex regulatory networks involving transcription factors (HIF-1, MYC, NRF2), signaling pathways (AMPK, mTOR, PI3K-AKT), and epigenetic modifications