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No controlled human trials confirm the frequency or severity of the symptoms

Impairment of hippocampal neurogenesis leads to learning and memory dysfunction, potentially by decreasing cell survival

Everything else is fair game if you can show outcome quality at least equal to the current manual baseline

If available, sonication is preferred for dissolution

So, when single dose pharmacokinetics are studied, the half-life of a drug is ideally determined after intravenous (iv) administration of the drug