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In addition, with the rise of global profiling strategies such as metabolomics, transcriptomics and large-scale proteomics leading to further delineation of the mechanisms of action of vitamin C, future clinical trials may be designed based on more refined rationales

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Interestingly, it has been previously reported that LMP2A enhances MYC driven lymphomagenesis through activation of the PI3K-pathway (181183), suggesting that activation of PI3K by LMP2A might be an alternative and/or convergent mechanism to the one driven by TCF3 / ID3 mutations

These models highlight distinct pathological and temporal features of AD, including early synaptic changes and amyloid accumulation, providing valuable tools for studying disease progression and potential therapeutic targets

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