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A 10 -6 M concentration of AngII (MedChemExpress, USA) was used to induce an in vitro hypertensive environment

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With the cationic groups, this hollow MSNs (Figures 2EH) showed higher loading capacity toward negative proteins such as -Gal and better cellular uptake performance by up to 40-fold and 5-fold compared to free protein or protein loaded in unmodified MSNs