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The resulting BAM files had PCR duplicates, mitochondrial reads, and ENCODE blacklist 107 features removed before further analysis using Picard v3.4.0 (Broad Institute, 2019), samtools v1.13 93 , and bedtools v2.30.0 108 , respectively

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In addition to an antioxidant role, AA acts at the molecular level as a cofactor for enzymes such as dopamine hydroxylase (EC 1.14.17.1), influencing the concentration of neurotransmitters, improving lysosomal protein degradation and mediating the consumption of monosodium glutamate (MSG) [43]

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Autophagy, on the other hand, involves the degradation of damaged organelles or proteins through autophagosomes, and while it can be protective under stress conditions, excessive autophagy can also lead to cell death

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