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Direct DNA Interaction : Once within the nucleus, this compound purportedly interacts directly with DNA through electrostatic attractions and specific hydrogen bonding with nucleotide sequences [1]

23 This is especially important in the brain and airways, where HNMT is the primary clearance pathway

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Bhutada G, Menard G, Bhunia RK, Hapeta PP, Ledesma-Amaro R, Eastmond PJ (2022) Production of human milk fat substitute by engineered strains of Yarrowia lipolytica

Docking substrates into the active site of the mutant Asn240Lys suffered from steric and entropic problems as Lys at position 240 oscillates (as evidenced by docking showing a wide range of different Lys240 positions), thereby obstructing access to the active site

This is the immune system recognizing the modified peptide as foreign and mounting a response against it