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Then, D-CuP loadedROS- responsive hydrogel was prepared and the preparation process was illustrated in Fig

Research shows it raises gene activity in healing models

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Growth factors are major regulators of angiogenesis, including vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), and platelet-derived growth factor (PDGF)

Experimental verification in cell lines observed inconsistent results, although NF-B signaling and SHh-Gli1 signaling activation were observed in both PC3 and DU145 cell lines, whereas in PC3 cell lines, Gli1 activation was only dependent on SHh, while in DU145 cells, Gli1 expression was neither dependent on SHh nor NF-B