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Any observed clinical changes in trials are specific to those study designs and should not be generalized as established therapeutic effects outside a regulated research context

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Funding The study was supported by the Henan Province Science and Technology Project (182102310112, ZY), the National S&T Major Project of China (2018ZX10301201-008), National Natural Science Foundation of China (81600506), National Key Research and Development Program of China (2018YFC2000501), and China Postdoctoral Science Foundation (2017464 and 20182814)

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