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This orphan status has created a dichotomy in the scientific community: while empirical evidence from animal models and human clinical trials in the 1980s demonstrated significant therapeutic potential, particularly in addiction and stress management, the lack of a defined molecular pathway has stalled its development into a licensed pharmaceutical agent

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[DOI] [PubMed] [Google Scholar] 112.Blher M, Aras M, Aronne LJ, et al

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