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siRNA-AKT#1:CCATGAACGAGTTTGAGTA;siRNA-AKT#2:GTGCCACTATGAAGACATT

In the CALERIE trial, a 2-year randomized controlled multicenter phase 2 clinical trial with 220 adults (age 2050 years), a 1225% reduction in calorie intake did not reduce biological age but slowed the pace of aging using the DunedinPACE DNAm algorithm 98