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SLC25A48 controls mitochondrial choline import and metabolism

Data for both OCR and rates of hydroperoxide generation were normalized by milligrams of muscle bundle wet weights

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Triggered by mitochondrial oxidative stress, Ca 2+ overload, dysregulation of iron homeostasis, mitochondrial DNA defects, and disruption of mitochondrial quality control (MQC), programmed cell death subsequently ensues encompassing apoptosis, pyroptosis, necroptosis, and ferroptosis [17]

The control algorithm was refined after the first 24 cases to reduce exposure to hyperoxia