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Biol Pharm Bull 39(2):199206 Shen C, Li Q, Zhang YC, Ma G, Feng Y, Zhu Q et al (2010) Advanced glycation endproducts increase EPC apoptosis and decrease nitric oxide release via MAPK pathways

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Human umbilical vein endothelial cells (HUVECs) isolated from human umbilical cord were purchased from Lonza Walkersville, Inc

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Thus, bacterial LPS can induce a chronic inflammatory process triggering many diseases such as pathogenesis of Alzheimers disease, obesity, atherosclerosis, and others (Page et al., 2022)