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von Mutius et al., 1994b

Innovations in genomics and big data analytics for personalized medicine and health care: a review

These include obesity, diet, gut microbiome dysbiosis, sedentary lifestyle, air pollutants, vitamin D deficiency, genetic factors, and even oral health (Lontchi-Yimagou, 2013)

The origins of spatial omics trace back to early tissue section analyses, which primarily relied on microscopy and immunohistochemistry

In fact, aging as well as degenerative and neuropsychiatric diseases, such as Parkinsons disease, Alzheimers disease, autism and schizophrenia, are associated with increased ROS production, the disruption of cellular GSH pools, and downregulation of GSH-dependent enzymes ( Because GSH does not readily penetrate the blood-brain barrier (BBB) ( de novo synthesis by two enzymes: -glutamate-cysteine ligase (GCL) and glutathione synthetase (GS) (Valdovinos-Flores and Gonsebatt, 2012)

Healthy and transformed cells depend on proteasomes to control the level of proteins linked to metabolism, survival and proliferation (177)