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P38MAPK inhibition The p38MAPK inhibitor SB203580, by decreasing the transcriptional activity of NF-B, has been shown to reduce the levels of mRNA of genes of SASP factors in human senescent cells (81)

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Similar to insulin in structure, IGF-1 levels are measured to help evaluate growth hormone level deficiencies such as hypopituitarism or growth hormone excesses such as acromegaly