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Our methods consist of PubMed search of pertinent clinical trials and reviews until August 22, 2023 using the key words mentioned in previous section

It is an X-linked dominant condition: X-linked dominant disorders produce a distinctive pattern (affected mothers transmit to sons and daughters

Brain Res Bull 116:6772 Qin W, Yang T, Ho L, Zhao Z, Wang J, Chen L, Zhao W, Thiyagarajan M, MacGrogan D, Rodgers JT, Puigserver P, Sadoshima J, Deng H, Pedrini S, Gandy S, Sauve AA, Pasinetti GM (2006) Neuronal SIRT1 activation as a novel mechanism underlying the prevention of alzheimer disease amyloid neuropathology by calorie restriction

Copper ionophores Copper ionophores transport copper into the cells, leading to an increase in intracellular copper levels and subsequent cell death

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SIRT3, as a deacetylase in mitochondria, modulates the transcription of mitochondrial in response to oxidative stress