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However, curcumin administration demonstrated effectively counteracted retinal degeneration, preventing alterations in the apoptotic cascade, MAPK, and small ubiquitin-like modifier 1 (SUMO-1) pathways, this therapeutic intervention preserved RGC viability and maintained normal histological architecture by stabilizing critical protein degradation mechanisms [42]

Accordingly, these findings show the beneficial effect of crude HEM in promoting OL maturation and myelination in the white matter of developing brains

10.1016/S0168-9525(00)02140-5 13

[The Working Group noted that the latter study was limited by the lack of quantitative or semiquantitative evaluation.] After a 24-hour at 320 g/mL (IC 25 ) or 480 g/mL (IC 50 ), aspartame induced phosphorylation of histone H2AX (H2AX), a biomarker of DNA double-strand breaks, in HepG2 (human hepatoblastoma) cells (Qu et al., 2019)