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389,390 Moreover, improvements in CRISPR-Cas9 technology present opportunities for accurate genetic and epigenetic alterations to rectify inherited genetic variants and epigenetic markers associated with DPN

PLoS One 12:e0175732

doi: 10.1038/s41586-020-2634-9 228 BuscarinuMCCerasoliBAnnibaliVPolicanoCLionettoLCapiMet al

Notably, this occurred in the absence of improved insulin sensitivity, neuroinflammation, brain mTORC1 signaling, or activation of brain autophagy all physiological and molecular changes that have been hypothesized to explain the ability of CR to slow the development or promote the clearance of A plaques