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244247] As to dose, there are multiple considerations: Adding an appropriate supportive dose without overdosing Assuring cofactor availability Form of glutathione supplement and bioavailability My recommendations generally are to have intake of a supplement with trace elements and other minerals like magnesium, a prenatal supplying the b-vitamin cofactors, and assuring at least 200-600 IU of tocopherols (depending on form)

2.4 Metabolic Activation of Anthraquinones-Induced Hepatotoxicity Anthraquinones are a class of functionally diverse natural products structurally related to anthracene, which widely exist in Polygonaceae medicinal plants, including Fallopia multiflora , Rheum palmatum and Aloe vera , these medicinal plants are massively consumed in the world

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8 Food Technology Department, Faculty of Agriculture, Benha University, Moshtohor, 13736, Egypt *These authors contributed equally to this work Correspondence: Shaaban K Osman, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Al-Azhar University, Assiut, 71524, Egypt, Tel +2 01129059936, Fax +2-088-312191, Email [email protected] Ahmed AH Abdellatif, Department of Pharmaceutics, College of Pharmacy, Qassim University, Qassim, 51452, Saudi Arabia, Email [email protected] Abstract: The real problem in pharmaceutical preparation is drugs poor aqueous solubility, low permeability through biological membranes, and short biological t 1/2