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Whereas excessive NO and nitrosative stress may result in airway injury, GSNO is an endogenous bronchodilator associated with airway smooth muscle relaxation (79) that protects against methacholine-induced airway hyperresponsiveness (98, 261) and NF-B activation during allergic airway inflammation (244)

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Ann Thorac Surg 69(2):369-75, 2000

Discovery and Design of Novel Small Molecule GSK-3 Inhibitors Targeting the Substrate Binding Site