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Very well-explained, Dr

LPS-induced mitochondrial DNA synthesis and release facilitate RAD50-dependent acute lung injury

For a subset of long Covid patients, Epstein-Barr virus is reactivated, which may be a driving factor in the fatigue and other symptoms

It also can inhibit ribonucleotide reductase, the enzyme responsible for DNA synthesis that contains a tyrosine radical

specifically, lycopene capsules and intralesional injected betamethasone were comparatively effective in increasing the mouth opening in patients at stage I, while betamethasone was more effective than lycopene in stage II, by contrast, lycopene was more potent than betamethasone in stage III

So in ALS, rather than driving pathology, the baseline microbiome might be trying to counteract it, and losing key microbes removes that brake on microglial activation