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Analytical methods included triple chemical fingerprinting and method validation (Table 3

Human clinical evidence was prioritized for synthesis, with preclinical evidence used to contextualize biologic plausibility

This helps keep thyroid hormone levels healthy

R PAPS synthesis is rate-limiting for sulfation capacity and depends on adequate intracellular sulfate (derived from cysteine catabolism, dietary sulfate, and sulfite oxidase activity)

In contrast, a negative effect could involve suppression of methionine adenosyltransferase activity, which can reduce the provision of methyl groups required for ETH biosynthesis [145]

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