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In addition, N-acetylcysteine (NAC) and ceftriaxone (CEF) interfered with MCAO rats to down-regulate the expression of SLC7A11 in neurons and astrocytes and induced cerebral ischemic tolerance ( mediates ferroptosis after ischemic stroke, but it is still uncertain whether it is involved in the regulation of neuronal ferroptosis after hemorrhagic stroke, and the role of system Xc in glutamate toxicity and ferroptosis after stroke remains arcane and requires further exploration
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There have also been studies demonstrating the key roles of other amino acids in the regulation of T cells ( in vitro treatment with SAM or MTA promoted the expression of exhaustion marks, inhibited IFN- expression, and caused a closed chromatin structure in human CD8+ T cells ( MAT2A knockout protected tumor-infiltrating CD8+ T cells from exhaustion in a syngeneic mouse tumor model ( Figure 2 Perspective on methionine metabolism in T cell immunotherapy Improving cancer immunotherapy by targeting the methionine cycle of T cells is an area that remains unexplored
