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WD is caused by mutations in ATP7B , which encodes a transmembrane copper-transporting ATPase, leading to impaired copper homeostasis and copper overload in the liver, brain and other organs

DOI: 10.1073/pnas.1525093113 Kim, J.A., Roy, R.R., Zhong, H., Alaynick, W.A., Embler, E., Jang, C., Gomez, G., Sonoda, T., Evans, R.M., Edgerton, V.R

1 Introduction Pediatric low-grade glioma (pLGG, WHO grade 1 or 2) is the most common brain tumor class in children ( 2 Molecular landscape of pLGG Advances in sequencing technologies have aided in classifying the diverse spectrum of pLGG histopathology

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L-Methionine (4mg) An essential sulphur amino acid supporting normal methylation and homocysteine metabolism.*

The principle is based on the different membrane permeability to the membrane-impermeable fluorescent DNA intercalating agent PI which stains membrane-compromised cells (red fluorescence) [40]