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Over activation of glutamate receptors and the resulting Ca 2+ overload stimulates calpains which target cytoskeletal proteins, kinases and phosphatases, membrane receptors and transporters (Xu et al., 2009

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In neurodegeneration disease and the injuries of many organs such as the heart, brain, kidney, and liver, ferroptosis was identified as an important form of cell death that results in organ damage [7,8,9], suggesting that inhibiting ferroptosis could be an important way to limit organ damage in disorders

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