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358 Senescent chondrocytes induce senescence in other chondrocytes in cartilage by releasing SASP factors, such as IL-6, IL-1, and MCP1

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doi:10.3945/ajcn.2008.27338 Chen HG, Sheng LT, Zhang YB, et al

"I assume they considered everything before they went forward with that as they did and they would take advice from whoever was doing the legal work

Simultaneously, the mechanical properties of the ECM change significantly: the shear stiffness of the human nucleus pulposus increases from 12.5 kPa in Pfirrmann grade 116.5 kPa in grade V (Walter et al., 2017), collagen fibers thicken and become disorganized (Wuertz et al., 2007) (Table 1)

High mobility group box 1 (HMGB1): HMGB1 is a nuclear protein that plays essential roles within the cell, such as organizing genetic material and facilitating DNA repair