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The choice of animal models to explore the in vivo activity of nAbs and their mechanisms of action is an important one and differences between models and conditions can be anticipated

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Cryobiology 58(2):225231 Xue W, Li H, Xu J, Yu X, Liu L, Liu H, Zhao R, Shao Z (2024) Effective cryopreservation of human brain tissue and neural organoids

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Abbreviations AD: Alzheimers disease ASD: Autism spectrum disorder CCI: Chronic constriction injury CNS: Central nervous system DNA: Deoxyribonucleic acid GCS: Glycine cleavage system Glu: Glutamate GlyR: Strychnine-sensitive glycine receptor GlyT1: Glycine transporter type 1 GlyT2: Glycine transporter type 2 IPSP: Inhibitory postsynaptic potential mRNA: Messenger ribonucleic acid MCAO: Middle cerebral artery occlusion Na/K-ATPase: Sodium-potassium ATPase nNOS: Neuronal nitric oxide synthase NMDAR: N-Methyl-D-aspartate receptor OGD: Oxygen-glucose deprivation pCREB: Phosphorylated cAMP response element-binding protein PD: Parkinsons disease PROT: Proline transporter PSD-95: Postsynaptic density protein 95 SCZ: Schizophrenia SHMT: Serine hydroxymethyltransferase SLC: Solute carrier family SLC6A5: Gene encoding GlyT2 SLC6A7: Gene encoding PROT SLC6A9: Gene encoding GlyT1 VIAAT: Vesicular inhibitory amino acid transporter References Achat-Mendes C, Nic Dhonnchadha B, Platt DM, Kantak KM, Spealman RD (2012) Glycine transporter-1 inhibition preceding extinction training inhibits reacquisition of cocaine seeking

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