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These observed changes may be due not only to high fat and low carbohydrate content in the diet but also to low protein intake, since adequate protein levels are important for maintaining bone health 39

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Therefore, lipopolysaccharide translocated to the liver (as in IBD) [73] could ameliorate PSC in IBD-PSC

Abbreviations ACLF: Acute-On-Chronic Liver Failure ALF: Acute liver failure ALLO: Allopregnanolone BBB: Bloodbrain barrier BCAAs: Branched-chain amino acids BDL: Bile-duct ligated cGMP: Cyclic guanosine monophosphate CFF: Critical Flicker Frequency CHE: Covert hepatic encephalopathy CHESS: Clinical Hepatic Encephalopathy Staging Scale CLF: Chronic liver failure CRT: Continuous Reaction Time CSF: Cerebrospinal fluid EEG: Electroencephalogram FMT: Fecal microbiota transplantation GPB: Glycerol phenylbutyrate HE: Hepatic encephalopathy HESA: Hepatic Encephalopathy Scoring Algorithm ICT: Inhibitory Control Test ISHEN: Society for Hepatic Encephalopathy and Nitrogen Metabolism LOLA: l-Ornithine and L-aspartate MARS: Molecular Adsorbent Recirculating System mHE: Minimal hepatic encephalopathy NKA: Na + K + ATPase OHE: Overt hepatic encephalopathy OP: Ornithine phenylacetate PEG: Polyethylene glycol PHES: Psychometric Hepatic Encephalopathy Score RBANS: Repeatable battery for the assessment of neuropsychological status RCTs: Randomized controlled trials SIRS: Systemic inflammatory response syndrome THDOC: Tetradehydrodeoxycorticosterone References American Association for the Study of Liver D, European Association for the Study of the L

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