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This method was efficient and phenotypically corrected the heterozygous mouse model of disease (Shangaris et al., 2019)

To this end, we developed a composite scoring system that integrates feature importance with a linearity metric (R), enabling the prioritization of reactions whose flux magnitudes exhibit a predictable relationship with the phenotypic outcome (see Methods)

Indeed, previous research has indicated that the vaginal microenvironment plays a crucial role in shaping the progression of HPV infection and the development of cervical lesions

Aggarwal V, Tuli HS, Thakral F et al (2020) Molecular mechanisms of action of hesperidin in cancer: recent trends and advancements

The mice were assessed for their behavior, histopathology, and biochemistry on the fourteenth day after birth