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The compounds that were effective across multiple models were further tested as single agents and in combination with a clinically relevant protocol mimicking COJEC 12 , the five-chemotherapy cocktail (cisplatin, vincristine, carboplatin, etoposide and cyclophosphamide) that is the first line of action to treat HR-NB patients set by the International Society of Pediatric OncologyEuropean Neuroblastoma (SIOPEN) 6

Linear regression analysis (line fitting) was performed using GraphPad Prism Software (version 9.5.1) (GraphPad Software, Inc.)

A 5 mg vial reconstituted with bacteriostatic water yields about 5.0 mg/mL

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I am worried since this is a joint and I dont see how causing trauma to a joint will make it better