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At the same time, the enhancement of proton pump activity, abnormal blood vessels, overexpression of carbonic anhydrase, and regulation of hypoxia-inducing factors all work together to cause significant acidification of TME ( Song has developed Cet-coupled DMAKO-20/PCL-PEOz micelles (DMAKO@PCL-PEOz-Cet) in which DMAKO-20 has been shown to have specific antitumor activity against CRC, but its hydrophobicity has been a puzzle (Song et al., 2024)

De Castro CMMB, Manhes De Castro R, Fernandes De Medeiros A, Queirs Santos A, Ferreira E Silva WT, De Lima Filho JL: Effect of stress on the production of O2- in alveolar macrophages.J Neuroimmunol2000, 108:68-72 46

these abnormalities were noted within a few days of initiation of acetylcysteine therapy and resolved gradually following discontinuance of the drug

Brain 135 , 2938 (2012)

Muscle carnitine deficiency in patients using valproic acid