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TABLE 2 Pharmacological antioxidant agents targeting redox imbalance in tendon repair

Issa GC, Mohanty V, Ayoub E, Wang F, Leighton J, Wu X, Bidikian A, Patsilevas T, Alaniz Z, Zarka J, Kanagal-Shamanna R, Futreal A, Daver N, Konopleva M, Navin N, Zhang J, Chen K, Andreeff M

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Using the homologous sequence search, we identified glutathione biosynthetic enzymes (Gcs1 and Gcs2), glutathione peroxidase (Gpx1), glutathione reductase (Glr1), and a family of glutathione S-transferases (Gsts)

Unfortunately, due to high polarity of target molecule, the LC-MS analysis suffers from low sensitivity

Neither the ARA 290 nor placebo treatment group changed significantly from baseline for the SFNSL when assessed at d 28 or d 56