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173 High expression of p65, SHh, and Gli1 was observed to be associated with poorer prognosis in patients with advanced prostate cancer

While normal cells preserve membrane localization of EAATs, their mislocalization in malignant cells together with up-regulation of xCT lead to aberrant handling of glutamate that induces high levels of glutamate in the extracellular space, as seen in gliomas (192) and in breast cancer, where endocrine therapy-resistant cells promote autophagy and glutamate import via EAAT2 (60, 193)

Indeed, a recent study reported no obvious decline in mitophagy in mice across all brain tissues with age, but rather region-specific dynamics (Rappe et al, 2024)

Bacterial cells were grown in tryptone-yeast extract-gelatin-volatile fatty acids-serum (TYGVS) medium at 37 C in an anaerobic chamber in the presence of 90% nitrogen, 5% carbon dioxide, and 5% hydrogen (Ohta et al, 1986)

Compared to the other groups, the obese CON group fed a high-fat diet (HFD) gained more weight (Fig