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7 , eabe5905 (2021)

Alzheimer's disease (AD) is a neurodegenerative disease represented by impaired learning, memory, and cognitive abilities [77]

In the present ADE study, alcohol reaccess provides conditioned cues such as ethanol odor, reported in heavy alcohol users to activate nucleus accumbens (Kareken et al., The doses of NAC and ASA used to reduce alcohol intake in the present study are within the range used for clinical studies

trx1 (JC677)

With the assistance of specific Cu chaperones, intracellular Cu(I) are transported to the specific metabolic processes in cytoplasm and nucleus through activating the target enzymes: antioxidant-1 (ATOX1) carries Cu(I) to nucleus (gene regulation) and Golgi apparatus (protein folding), copper chaperone for superoxide dismutase (CCS) carries Cu(I) to superoxide dismutase (SOD) (redox homeostasis), and cytochrome c oxidase 17 (COX17) carries Cu(I) to mitochondria (mitochondrial respiration) (Figure 1) (Chen et al., 2022)

DON treatment activates AMPK in cancer cells by increasing the AMP/ATP ratio and decreasing the expression of c-Myc proteins, thereby inhibiting glycolytic metabolism and suppressing cancer cell growth in vitro 145