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Nonclinical Toxicology 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility The carcinogenic potential of NEXIUM was assessed using studies of omeprazole, of which esomeprazole is an enantiomer

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doi: 10.1038/nrdp.2015.56 47 MeadowsJ

Cell culture and cytotoxicity detection The human lens epithelial cell line (HLEB3) was cultured in Dulbeccos Modified Eagles Medium (DMEM) with 10% fetal bovine serum (FBS) and maintained in a 37 C incubator with 5% CO 2

While much of the research remains in preclinical stages, early findings are promising