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Although similar doses of glucoraphanin and glucoerucin were given in the sprouts and supplement, the total amounts of SFN and ERN metabolites in the plasma and urine were much lower in the supplement group compared to the sprout group.[14] The subjects got more sulforaphane out of raw sprouts than the supplement

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30 Namazi N, Mahdavi R, Alizadeh M, Farajnia S

A decrease in its activity leads to diminished storage and release of ACh affecting directly its function

Vermeulen van Eck, Ineke WG (2014)

A Herxheimer reaction is typically: Temporary Associated with starting or changing treatment Followed by gradual improvement In contrast, worsening disease may involve sustained or progressive symptoms without improvement