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In plant TyrAs, an acidic residue at the corresponding 222 position confers ADH activity by directly interacting with the side chain amine of arogenate, and when mutated to a non-acidic Asn, switches to PDH activity (Schenck et al., 2017)

Activated macrophages control human adipocyte mitochondrial bioenergetics via secreted factors

Finally, the requirement for insulin receptor/IRS in insulin resistance has been tested through independent PI3K/Akt pathway activation via PDGF receptor overexpression

Mohebbi for help with initial experiments

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SOD2 targeted gene editing by CRISPR/Cas9 yields Human cells devoid of MnSOD