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The differences between mouse and human skin, hair cycling, hormonal systems, and immune responses all affect translation

this is especially relevant for individuals of childbearing potential 3 Changes in skin texture or tone these are often signs the cream is working, but should be discussed with the provider if concerning or prolonged Warnings & Precautions Introduce the cream gradually starting with every other evening for the first few weeks can help the skin adjust and reduce early irritation Avoid contact with the eyes, mouth, nostrils, and broken or sunburned skin Apply broad-spectrum sunscreen (SPF 30 or higher) every morning when using this cream Do not use on inflamed, windburned, or otherwise compromised skin Inform the provider of all other skincare products in use certain ingredients (e.g., other retinoids, strong acids, benzoyl peroxide) may increase irritation Women of childbearing potential should use effective contraception while using this cream due to the presence of both finasteride and estriol Use under the supervision of a licensed provider experienced with hormonal and anti-androgenic topical therapy Store as directed, typically in a cool, dry place away from direct light and heat Contraindications Known allergy or sensitivity to any active ingredient (estriol, finasteride, tretinoin, or niacinamide) Pregnancy finasteride is a Category X medication and must not be used by pregnant individuals or those who may become pregnant

doi: 10.1016/j.chom.2016.01.009 25 GhoshS.JiangN.FarrL.NgobeniR.MoonahS

Blood samples were examined before and after a 2 km rowing exercise

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They are not FDA-approved for the treatment of TN