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This targeted action on adipose tissue ensures that energy resources are utilized effectively, reducing unwanted fat accumulation without interfering with other physiological processes like glucose regulation

The mitochondrial unfolded protein response regulates hippocampal neural stem cell aging

Another possibility is that obesity could lower serum vitamin B12 levels through decreased dietary intake or absorption, increased catabolism, and sequestration in adipose tissue, or changes in the gut microbiota profiles which could affect the metabolism of vitamin B12

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The search strategy was initially developed for PubMed using keywords and MeSH terms and was then adapted to the other databases

Healthcare providers might prescribe such a high dose to correct a deficiency, but it is too much to take without medical supervision