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At this stage, we say the patient has overt or clinical hypothyroidism There is some debate as to the benefit of treating those with sub-clinical hypothyroidism in symptomatic patients with a high TSH, but normal T4 a trial of treatment may be suitable Hypothyroidism is typically treated with a daily dose of thyroxine 1.6 g/kg lean body weight daily

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During the aging process, the body's metabolism begins to slow down

In fact, the addition of NBDHEX, a strong and specific inhibitor of e-GST and other GST isoenzymes belonging to the alpha, pi and mu classes, 13 did not suppress this additional GST activity (Figure 2b), and curiously the activity was also found in the absence of GSH (Figure 2a)

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