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Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles

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As an essential tool to dig the potential molecular mechanisms of sorafenib resistance, sorafenib-resistant HCC lines were constructed by being exposed to sorafenib treatment for 23 days, and resistance was induced by adding step-wise elevating the sorafenib concentration into the medium during repeated passages [30] (Fig

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10.1136/bcr-2013-200723 8 AvgerinosK

Animal Model:0.5 million EGFR Del19/T790M/C797S Ba/F3 cells and 50% Matrigel gel were subcutaneously inoculated in Balb/c nude mice (female aged 6-8 weeks) [1] Dosage:20, 40 mg/kg Administration:p.o., once a day for 18 consecutive days Result:Significantly reduced tumor volume by 58% and 84% at doses of 20 mg/kg and 40 mg/kg