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doi: 10.1038/s41574-019-0218-2 63 MaennerM

General procedure for site-selective modification of proteins A solution of the protein of interest (1 mg/mL, 1 equiv) was prepared in 50 mM PB buffer, pH 7

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These studies underscore that the effects of serine might depend on the type of infiltrating immune cells (Tregs or Teffs) and their specific isomer, being an interesting target for supplementation in tumors with a high ratio of infiltrated Teffs/Tregs

Researchers recognize that transcriptomic data do not always align with proteomic signatures

Improving the selectivity of covalent inhibitors is critical and can be optimized through various means, including adjusting the reactivity and reversibility of the electrophile (warhead), 571,572 non-covalent scaffolds, dosage, etc