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Not because of microbial contamination (bacteriostatic water prevents that), but because oxidative degradation accelerates logarithmically after the 4-week mark

The oxidative inactivation of mitochondrial electron transport chain components and ATPase

At 60 h-post injection, the mice were sacrificed and the biodistribution determined upon fluorescence imaging of the respective organs

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Monozyten zirkulieren nach bergang aus dem Knochenmark nur 24 h im Blut, gehen dann ins Gewebe und zirkulieren nicht zurck ins Blut

Front Cell Neurosci 8:281 Araya LE et al (2021) Deorphanizing caspase-3 and caspase-9 substrates in and out of apoptosis with deep substrate profiling