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This can be a sign that youre dealing with a vitamin B12 deficiency

Figure 2 3 Discussion Here, we present two cases of de novo vitiligo, a Th1 cell-mediated inflammatory skin disease, following dupilumab therapy for AD

10.1515/CCLM.2011.234 43 Isordia-SalasI.Barinagarrementera-AldatzF.Leaos-MirandaA.Borrayo-SnchezG.Vela-OjedaJ.Garca-ChvezJ.et al (2010)

Vitamin B12, also known as cobalamin , is an essential water-soluble vitamin that supports several vital functions in the body: Red blood cell production Nervous system health DNA synthesis Energy metabolism Many people with fatigue, brain fog, or poor nutrient absorption are deficient in B12particularly those with gastrointestinal conditions (like IBS or celiac disease), vegans and vegetarians, or individuals taking certain medications like metformin or proton-pump inhibitors

At the same time, with the help of nanotechnology and immunoinformatics tools, as well as the combined application of immunotherapy strategies such as ICB, multi-epitope and multi-component tumor vaccines are continuously developed demonstrating strong immune response efficacy in vivo and in vitro experiments, which can achieve precise spatiotemporal delivery and produce lasting anti-tumor immune responses