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These multiple pathologies can be explained by the fact that HNE is a potent modulator of numerous cell processes such as oxidative stress signaling, cell proliferation, transformation or cell death

Serious adverse events occurred in 7.3% of patients in the SZC group and 8.1 % of patients in the placebo group

Oral supplements only provide about 20% absorption by the time it gets to the blood stream

These findings suggest that Nrf2 exerts a pivotal function in counteracting inherent oxidative stress throughout the pathological process of PD, thereby further supporting its therapeutic potential

Promising strategies include repurposed antidiabetic drugs (e.g., SGLT-2 inhibitors, GLP-1 receptor agonists), microbiome-targeted therapies (e.g., fecal microbiota transplantation), and novel immunomodulatory agents